About: Oncogene E1A     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Oncogene E1A
rdfs:subClassOf
Semantic_Type
  • Gene or Genome
Preferred_Name
  • Oncogene E1A
UMLS_CUI
  • C1709313
Legacy_Concept_Name
  • Oncogene_E1A
FULL_SYN
  • Oncogene E1APTNCI
  • E1ASYNCI
Gene_Encodes_Product
  • E1A Protein
DEFINITION
  • Viral Oncogene E1A encodes E1A Protein, a regulator of early viral gene transcription. E1A interacts with diverse cellular proteins to override host cell controls of cell cycle, differentiation or apoptosis. E1A reprograms gene expression and other processes, which leads to transformation. E1A interacts with general and specific transcription factors, co-activators and chromatin-modifying enzymes. Targeted proteins include pRbs, p300/CBP, cyclin/Cdk, transcriptional corepressor CtBP, YY1, RACK1 and SWI/SNF complex, as well as cAMP/PKA signal components. E1A N-terminus binds pRb and p300/CBP regulators. E1A C-terminus negatively modulates the N-terminus and interacts with CtBP. By binding COUP-TF repressor and decreasing NF-kB Class I enhancer binding, E1A can repress MHC Class I gene transcription and allow tumor cells to avoid lysis by cytotoxic T lymphocytes. E1A also determines susceptibility to NK cell lysis.NCI
code
  • C45505
is someValuesFrom of
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