About: Zalcitabine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Zalcitabine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Zalcitabine
NSC_Code
  • 606170
UMLS_CUI
  • C0012132
CAS_Registry
  • 7481-89-2
FDA_UNII_Code
  • 6L3XT8CB3I
Contributing_Source
  • FDA
ALT_DEFINITION
  • A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 40349
PDQ_Closed_Trial_Search_ID
  • 40349
Chemical_Formula
  • C9H13N3O3
Legacy_Concept_Name
  • Zalcitabine
CHEBI_ID
  • CHEBI:10101
FULL_SYN
  • ZalcitabinePTNCI
  • 2',3'-DideoxycytidineSYDTPNSC0606170
  • ddCABNCI
  • DideoxycytidineSYNCI
  • HividBRNCI
  • ZALCITABINEPTFDA6L3XT8CB3I
  • 2',3'-DideoxycytidineSNNCI
DEFINITION
  • A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zalcitabine preferentially inhibits the gamma form of DNA polymerase present in tumor cell mitochondria, resulting in the inhibition of tumor cell mitochondrial DNA replication and tumor cell death. (NCI04)NCI
code
  • C430
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