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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Diazooxonorleucine
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Antibiotic
Preferred_Name
  • Diazooxonorleucine
NSC_Code
  • 7365
UMLS_CUI
  • C0012020
CAS_Registry
  • 764-17-0
PDQ_Open_Trial_Search_ID
  • 39224
PDQ_Closed_Trial_Search_ID
  • 39224
Legacy_Concept_Name
  • Diazooxonorleucine
FULL_SYN
  • DiazooxonorleucineSYDTPNSC0083700
  • 6-diazo-5-oxo-norleucineSNNCI
  • DONABNCI
  • 6-diazo-5-oxo-L-norleucineSNNCI
  • DiazooxonorleucinePTNCI
  • 6-DIAZO-5-OXO-L-NORLEUCINESYDTPNSC0007365
DEFINITION
  • An L-glutamine diazo analogue amino acid antibiotic isolated from a species of the bacterial genus Streptomyces with potential antineoplastic activity. Diazooxonorleucine inhibits several glutamine-dependent biosynthetic pathways involved in the syntheses of D-glucosamine phosphate, purines and pyrimidines. This agent inhibits phosphate-activated glutaminase, a key enzyme for the synthesis of releasable glutamine, depleting cells of this essential amino acid and reducing their capacity to proliferate.NCI
code
  • C427
sameAs
http://linked.open...y/mesh/hasConcept
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