About: Interleukin 12 Receptor Beta     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:DeprecatedClass, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Interleukin 12 Receptor Beta
rdfs:subClassOf
Semantic_Type
  • Receptor
Preferred_Name
  • Interleukin 12 Receptor Beta
OLD_PARENT
  • Protein_or_Riboprotein_Complex
OLD_KIND
  • Gene_Product_Kind
OLD_ROLE
  • Gene_Product_Has_Biochemical_Function|Cytokine_Receptor
  • Gene_Product_Plays_Role_In_Biological_Process|Host_Defense_Mechanism
  • Gene_Product_Plays_Role_In_Biological_Process|Receptor_Signaling
  • Gene_Product_Plays_Role_In_Biological_Process|Inflammatory_Response
Concept_Status
  • Retired_Concept
FULL_SYN
  • Interleukin 12 ReceptorSYNCI
  • High Affinity Interleukin 12 ReceptorSYNCI
  • Interleukin 12 Receptor BetaPTNCI
  • High Affinity Interleukin 12 Receptor BetaSYNCI
DEFINITION
  • Human high affinity Interleukin 12 Receptor Beta (Type I Cytokine Receptor 2 Family) is composed of Interleukin 12 Receptor Beta 1 Chain (IL12RB1 Gene) and Interleukin 12 Receptor Beta 2 Chain (IL12RB2 Gene), both type I transmembrane proteins involved in signal transduction and each containing 5 FNIII domains; a box 1 motif required for JAK interaction/activation; and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. IL12RB1/2 activity appears to contribute to host defense mechanisms and the inflammatory response. Both IL12RB1 oligomers and IL12RB2 oligomers act as a low affinity IL12 receptor. (NCI)NCI
DesignNote
  • See 'Interleukin 12 Receptor'
code
  • C41057
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