About: Riboadenylate Transferase     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Riboadenylate Transferase
rdfs:subClassOf
Semantic_Type
  • Enzyme
Preferred_Name
  • Riboadenylate Transferase
UMLS_CUI
  • C0032401
Legacy_Concept_Name
  • Riboadenylate_Transferase
FULL_SYN
  • Polynucleotide AdenylyltransferaseSYNCI
  • Riboadenylate TransferasePTNCI
DEFINITION
  • Nuclear or cytoplasmic human Riboadenylate Transferases (Poly A Polymerase Family) catalyze template-independent post-transcriptional extension of the 3 prime end of an RNA strand by nonspecific and CPSF/AAUAAA-dependent polyadenylation activity during eukaryotic mRNA maturation. The N-terminal region appears required for nonspecific polymerase activity, while the N- and C-termini are required for specific polymerase activity. Specificity may occur through C-terminus interaction with CPSF, regulated by phosphorylation. The poly(A) reaction involves endoribonucleolytic pre-RNA cleavage at the poly(A) site and synthesis of the poly(A) tail. (NCI)NCI
code
  • C41038
sameAs
http://linked.open...y/mesh/hasConcept
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