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AttributesValues
rdf:type
rdfs:label
  • Multidrug Resistance Induction
rdfs:subClassOf
Semantic_Type
  • Physiologic Function
Preferred_Name
  • Multidrug Resistance Induction
UMLS_CUI
  • C1513738
Legacy_Concept_Name
  • Multidrug_Resistance_Induction
FULL_SYN
  • Multidrug Resistance InductionPTNCI
DEFINITION
  • Multidrug Resistance Induction involves initiation of activities of biologic molecules or complexes involved in processes that increase the ability of cancer cells to counteract, defeat, or withstand the effects of multiple chemotherapeutic agents. Mechanisms involve expression of multidrug efflux pumps (p-glycoprotein), altered glutathione metabolism, decreased topoisomerase II activity, and changes in various cellular proteins.NCI
code
  • C40817
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