About: Cyclosporine

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Cyclosporine
rdfs:subClassOf	Multidrug Resistance Modulator IMMUNE SUPPRESSANTS nodeID://b663682 nodeID://b663683 nodeID://b663684
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance
Preferred_Name	Cyclosporine
NSC_Code	290193
UMLS_CUI	C0010592
CAS_Registry	59865-13-3
Accepted_Therapeutic_Use_For	Allogenic transplants; prophylaxis of organ rejection in bone marrow; kidney; liver and heart transplants; psoriasis; rheumatoid arthritis; various diseases that involve autoimmune response
In_Clinical_Trial_For	Prevention of bone marrow, organ transplant and stem cell rejection; graft versus host disease in patients with various conditions Prevention of bone marrow; organ transplant and stem cell rejection; graft versus host disease in patients with various conditions
FDA_UNII_Code	83HN0GTJ6D
Contributing_Source	FDA
ALT_DEFINITION	A drug used to help reduce the risk of rejection of organ and bone marrow transplants by the body. It is also used in clinical trials to make cancer cells more sensitive to anticancer drugs.NCI-GLOSS
PDQ_Open_Trial_Search_ID	39201
PDQ_Closed_Trial_Search_ID	39201
Chemical_Formula	C62H111N11O12
Legacy_Concept_Name	Cyclosporine
CHEBI_ID	CHEBI:4031
FULL_SYN	CYCLOSPORINEPTFDA83HN0GTJ6D CiclosporinSYDTPNSC0290193 CiclosporinSYNCI CyclosporinSYNCI CyclosporinePTNCI 27-400SYDTPNSC0290193 Cyclosporin ASYNCI Cyclosporin ASYDTPNSC0290193 CsAABNCI cyclosporinePTNCI-GLOSSCDR0000045187 CyclosporinePTDCP00088 27-400CNNCI NeoralBRNCI SangCyaBRNCI OL 27-400CNNCI SandimmunBRNCI SandimmuneBRNCI
DEFINITION	A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. (NCI04)NCI
code	C406
sameAs	CYCLOSPORINE CYCLOSPORINE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0025279
is someValuesFrom of	nodeID://b644909 nodeID://b644910 nodeID://b646301 nodeID://b656788 nodeID://b656873 nodeID://b656879 nodeID://b656882 nodeID://b656884 nodeID://b659538 nodeID://b659757 nodeID://b659760 nodeID://b662251 nodeID://b662255 nodeID://b663687 nodeID://b663689 nodeID://b663695 nodeID://b663697 nodeID://b663700 nodeID://b663705 nodeID://b663709 nodeID://b663710 nodeID://b663719 nodeID://b663722 nodeID://b663726 nodeID://b663728 nodeID://b663730 nodeID://b663734 nodeID://b663736 nodeID://b663740 nodeID://b663741 nodeID://b663745 nodeID://b663747 nodeID://b663748 nodeID://b663751 nodeID://b663755 nodeID://b663758 nodeID://b663760 nodeID://b663761 nodeID://b663765 nodeID://b663766 nodeID://b663770 nodeID://b663772 nodeID://b663774 nodeID://b663776 nodeID://b663779 nodeID://b663781
is sameAs of	CYCLOSPORINE CYCLOSPORINE CYCLOSPORINE

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