About: Diltiazem Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Diltiazem Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Diltiazem Hydrochloride
UMLS_CUI
  • C0700940
CAS_Registry
  • 33286-22-5
FDA_UNII_Code
  • OLH94387TE
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 40122
PDQ_Closed_Trial_Search_ID
  • 40122
Chemical_Formula
  • C22H26N2O4S.HCl
Legacy_Concept_Name
  • Diltiazem_Hydrochloride
CHEBI_ID
  • CHEBI:645509
FULL_SYN
  • Diltiazem HydrochloridePTNCI
  • Diltiazem HClSYNCI
  • DILTIAZEM HYDROCHLORIDEPTFDAOLH94387TE
  • CardizemBRNCI
  • Diltiazem HydrochloridePTDCP32070
DEFINITION
  • A benzothiazepine calcium channel blocking agent. Diltiazem hydrochloride inhibits the transmembrane influx of extracellular calcium ions into select myocardial and vascular smooth muscle cells, causing dilatation of coronary and systemic arteries and decreasing myocardial contractility. Because of its vasodilatory activity, this agent has been shown to improve the microcirculation in some tumors, thereby potentially improving the delivery of antineoplastic agents to tumor cells. (NCI04)NCI
code
  • C398
sameAs
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