About: Gene Expression Regulation by Vitamin D Receptor Pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Gene Expression Regulation by Vitamin D Receptor Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Gene Expression Regulation by Vitamin D Receptor Pathway
rdfs:subClassOf	Regulatory Pathway
Semantic_Type	Functional Concept
Preferred_Name	Gene Expression Regulation by Vitamin D Receptor Pathway
UMLS_CUI	C1517487
BioCarta_ID	h_vdrPathway
ALT_DEFINITION	The vitamin D receptor, VDR is the mediator of all genomic actions of vitamin D3 and its analogs. It belongs to a family of ligand induced transcription factors, nuclear receptors (NRs). Vitamin D3 is the main regulator of calcium homeostasis and is critical in bone formation. It is also involved in controlling cellular growth, differentiation, and apoptosis, which makes synthetic vitamin D3 analogues interesting for therapy of such diseases as cancer and psoriasis. NRs are comprised of an amino-terminal activation function domain AF-1, the DNA-binding domain, a hinge region, and a carboxy-terminal ligand-binding domain containing a second activation function, AF-2. VDR acts primarily as a heterodimer with the retinoid X receptor (RXR) on vitamin D response elements (VDREs). It interacts with the transcription machinery and nuclear receptor coactivators or corepressors to regulate target gene activity. NR's coregulators can be divided into 3 major classes: 1) ATP-dependent chromatin remodeling complexes that are involved in the location and association of nucleosomes with DNA; 2) Enzymes that catalyze modifications of histone tails to regulate histone-histone and histone-DNA interactions; 3) General transcription factor adaptors that bridge the functions between regulators and basal transcription factors. A novel multifunctional ATP-dependent chromatin remodeling complex, WINAC, directly interacts with the vitamin D receptor. It contains BRG1 or hBRM as ATPase subunits as all SWI/SNF complexes do, but it also has subunits associated with DNA replication (TopoII and CAF-1p150) and transcript elongation through nucleosomes (FACTP140) not found before in SWI/SNF complexes. WINAC also contains the Williams syndrome transcription factor (WSTF). WSTF appears to function as a platform protein for the assembly of components in WINAC, and it interacts directly with the vitamin D receptor in a ligand-independent manner. WINAC and vitamin D receptor are targeted to vitamin D responsive promoters in the absence of ligand to both positively and negatively regulated genes. WINAC may rearrange the nucleosome array around the positive and negative VDREs, thereby facilitating the coregulatory complex's access for further transcription control. Upon ligand binding, two HAT complexes, p160/CBP and TRRAP/PCAF, coactivate the NR function. The p160 proteins (SRC protein family) interact directly with an NR activation surface AF2 and serve as platforms for the recruitment of histone-modifying enzymes, including CBP/p300 and methyltransferases. The SRC/p160 family members SRC-1 and p/CIP, as well as CBP and p300 contain intrinsic histone acetyltransferase activity (HAT). Both the HAT activity and the histone methyltransferase activity may cooperate in histone modification and facilitate nucleosome remodeling and recruitment of transcriptional machinery. A third group of coactivators is represented by thyroid receptor-associated proteins (TRAP)/vitamin D receptor-interacting proteins (DRIP). This complex may play a role by directly contacting the basal transcriptional machinery. As the VDR/RXR heterodimer also represses transcription in a ligand-dependent manner through negative VDRE (nVDRE), a number of corepressor proteins such as NCoR and ALIEN may also be recruited to the surface of the receptor. They, too, function as platforms but serve to recruit enzymes such as histone deacetylases. WINAC association with VDR facilitates targeting of a putative corepressor complex to the nVDRE.BIOCARTA
Legacy_Concept_Name	Gene_Expression_Regulation_by_Vitamin_D_Receptor_Pathway
FULL_SYN	Control of Gene Expression by Vitamin D ReceptorPTBIOCARTA Gene Expression Regulation by Vitamin D Receptor PathwayPTNCI
code	C39263
is someValuesFrom of	nodeID://b643120 nodeID://b643241 nodeID://b648077 nodeID://b648088 nodeID://b648092 nodeID://b648097 nodeID://b649325 nodeID://b652392 nodeID://b654795 nodeID://b654836 nodeID://b668020 nodeID://b668985 nodeID://b677943 nodeID://b680136 nodeID://b680264 nodeID://b694807 nodeID://b694825 nodeID://b694838 nodeID://b694863 nodeID://b697444 nodeID://b697471 nodeID://b697488 nodeID://b697507 nodeID://b698857 nodeID://b700167 nodeID://b702522 nodeID://b707355 nodeID://b709027 nodeID://b710219 nodeID://b710427 nodeID://b710446 nodeID://b710453 nodeID://b710459 nodeID://b710473 nodeID://b710594 nodeID://b718202 nodeID://b718659 nodeID://b720062 nodeID://b721155 nodeID://b722476 nodeID://b723049 nodeID://b726356

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 18 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software