About: Toll-Like Receptor Pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Toll-Like Receptor Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Toll-Like Receptor Pathway
rdfs:subClassOf	Immune Response Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	Toll-Like Receptor Pathway
UMLS_CUI	C1519544
BioCarta_ID	h_tollPathway
ALT_DEFINITION	The innate immune response responds in a general manner to factors present in invading pathogens. Bacterial factors such as lipopolysaccharides (LPS, endotoxin), bacterial lipoproteins, peptidoglycans, and also CpG nucleic acids activate innate immunity as well as stimulating the antigen-specific immune response and triggering the inflammatory response. Members of the toll-like receptor (TLR) gene family convey signals stimulated by these factors, activating signal transduction pathways that result in transcriptional regulation and stimulate immune function. TLR2 is activated by bacterial lipoproteins, TLR4 is activated by LPS, and TLR9 is activated by CpG DNA; peptidoglycan recognition protein (PGRP) is activated by peptidoglycan (PGN). The downstream signaling pathways used by these receptors are similar to that used by the IL-1 receptor, activating the IL-1 receptor associated kinase (IRAK) through the MyD88 adaptor protein, and signaling through TRAF-6 and protein kinase cascades to activate NF-kB and Jun. NF-kB and c-Jun activate transcription of genes such as the proinflammatory cytokines IL-1 and IL-12. Several reports have suggested that the functional outcomes of signaling via TLR2, TLR4, and PGRP are not equivalent. For example, while the LPS-induced, p38-dependent response was dependent upon PU.1 binding, the PGN-induced, p38 response was not. The intracellular receptor for PGN, PGRP, is conserved from insects to mammals. In insects, PGRP activates prophenoloxidase cascade, a part of the insect antimicrobial defense system. Because mammals do not have the prophenoloxidase cascade, its function in mammals is unknown. However, it was suggested that an identical protein Tag7 was a tumor necrosis factor-like (TNF-like) cytokine. PGRP/Tag7 possesses cytotoxicity and triggers intranucleosomal DNA fragmentation in target cells in the same way as many known members of the TNF family. Fragmentation of DNA is one of the characteristics of apoptosis. The possibility that in another system, PGRP/Tag7 would induce NF-kB activation, as observed for TRAIL (TNF-related apoptosis-inducing ligand) receptors cannot be ruled out.BIOCARTA
Legacy_Concept_Name	Toll-Like_Receptor_Pathway
FULL_SYN	Toll-Like Receptor PathwayPTNCI Toll-Like Receptor PathwayPTBIOCARTA
code	C39257
is someValuesFrom of	nodeID://b653099 nodeID://b653112 nodeID://b667800 nodeID://b668824 nodeID://b668868 nodeID://b672627 nodeID://b672697 nodeID://b680922 nodeID://b681327 nodeID://b681888 nodeID://b682695 nodeID://b683285 nodeID://b683633 nodeID://b684710 nodeID://b684802 nodeID://b688265 nodeID://b688477 nodeID://b688751 nodeID://b688776 nodeID://b688809 nodeID://b688843 nodeID://b688854 nodeID://b688870 nodeID://b689028 nodeID://b689322 nodeID://b689690 nodeID://b690741 nodeID://b695073 nodeID://b695318 nodeID://b700162 nodeID://b700855 nodeID://b702515 nodeID://b706830 nodeID://b712181 nodeID://b717002 nodeID://b717019 nodeID://b717806 nodeID://b717811 nodeID://b717818 nodeID://b717825 nodeID://b717830 nodeID://b717840 nodeID://b718099 nodeID://b718183 nodeID://b718487 nodeID://b719930 nodeID://b719941 nodeID://b719948 nodeID://b719957 nodeID://b719966 nodeID://b719972 nodeID://b719983

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 18 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software