About: T Cell Receptor Signaling Pathway BioCarta

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Attributes	Values
rdf:type	Class
rdfs:label	T Cell Receptor Signaling Pathway BioCarta
rdfs:subClassOf	Signaling Pathway Immune Response Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	T Cell Receptor Signaling Pathway BioCarta
UMLS_CUI	C1325934
BioCarta_ID	h_tcrPathway
ALT_DEFINITION	The T Cell Receptor plays a key role in the immune system. The specificity of the receptor is governed by the binding site formed from the mature alpha and beta chains or gamma and delta chains in gamma/delta T Cells. It is the ability of this receptor to bind a complex of foreign peptide in the groove of an MHC molecule that leads to T cell activation. Upon activation the T cell can assist in activating other cells or carry out cytolytic attacks depending on the particular T cell type. The CD3 complex and CD4 (Th cells) or CD8 (Tc cells) work to transmit the activation signal to the T cell's transcriptional machinery upon engagement of the receptor.BIOCARTA
Legacy_Concept_Name	T_Cell_Receptor_Signaling_Pathway
FULL_SYN	T Cell Receptor Signaling PathwayPTBIOCARTA T Cell Receptor Signaling Pathway BioCartaPTNCI
code	C39246
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