About: TCR Activation Pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: TCR Activation Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	TCR Activation Pathway
rdfs:subClassOf	Immune Response Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	TCR Activation Pathway
UMLS_CUI	C1515145
BioCarta_ID	h_tcraPathway
ALT_DEFINITION	T cell activation is initiated by recognition of antigen by the T cell receptor (TCR) in the context of Class II MHC on an antigen-presenting cell. The T cell receptor contains multiple subunits and interacts with several factors to transduce antigen-stimulated T cell activation. One of the key steps that initiates receptor activation is the tyrosine phosphorylation of TCR subunits by the src family protein kinases Lck and Fyn. T cell receptor phosphorylated by Lck and Fyn recruits the ZAP-70 protein kinase to the receptor complex, which becomes activated and stimulates downstream pathways like the Map kinase cascade. The CD45 protein tyrosine phosphatase activates Lck and Fyn by dephosphorylating these proteins and is required for TCR activation. Association of the CD4 coreceptor with Lck may also be involved in Lck activation.BIOCARTA
Legacy_Concept_Name	TCR_Activation_Pathway
FULL_SYN	TCR Activation PathwayPTNCI Lck and Fyn tyrosine kinases in initiation of TCR ActivationPTBIOCARTA
code	C39245
is someValuesFrom of	nodeID://b653322 nodeID://b653354 nodeID://b653380 nodeID://b653405 nodeID://b653497 nodeID://b653520 nodeID://b672981 nodeID://b678297 nodeID://b678381 nodeID://b685753 nodeID://b701347 nodeID://b705628 nodeID://b716716 nodeID://b716748 nodeID://b716775 nodeID://b716849 nodeID://b726426 nodeID://b726462

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 18 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software