About: B-Cell Immune Response Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	B-Cell Immune Response Pathway
rdfs:subClassOf	Immune Response Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	B-Cell Immune Response Pathway
UMLS_CUI	C1511003
BioCarta_ID	h_tall1Pathway
ALT_DEFINITION	APRIL and BAFF (also called TALL-I and BLyS) are TNF family members that act as ligands for the BCMA and TACI receptors. Both APRIL and BAFF bind to both the BCMA and TACI receptors to activate the humoral immune response, stimulating B cell immunoglobulin production and proliferation. BAFF is found as a membrane bound form in T cells and a soluble form that is released from the cell to stimulate B cell proliferation and differentiation. As members of the TNF receptor gene family, BCMA and TACI interact with TRAF family members to transduce signals downstream to NF-kappaB activation and MAP kinase pathways. Abnormally active BAFF or APRIL signaling may play a role in autoimmune disorders such as lupus.BIOCARTA
Legacy_Concept_Name	B-Cell_Immune_Response_Pathway
FULL_SYN	TACI and BCMA stimulation of B cell immune responsesPTBIOCARTA B-Cell Immune Response PathwayPTNCI
code	C39243
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