About: dsRNA Induction Pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: dsRNA Induction Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	dsRNA Induction Pathway
rdfs:subClassOf	Immune Response Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	dsRNA Induction Pathway
UMLS_CUI	C1515618
BioCarta_ID	h_rnaPathway
ALT_DEFINITION	One defense against viral infection is provided by PKR, double-stranded RNA activated protein kinase. When PKR interacts with dsRNA found in cells during viral infection, PKR phosphorylates itself and cellular proteins including the translation factor elF2a and the transcription factor NF-kB. The repression of translation caused by phosphorylation of elF2a prevents cells from producing viral proteins and creating infectious viral particles. PKR phosphorylation of I-kB kinase activates NF-kB to induce transcription of inflammatory factors and stimulate an immune response that impedes viral infection. The PKR kinase is induced by interferon and some of the anti-viral activity of interferon may be mediated by PKR. Some viruses have evolved mechanisms to inactivate PKR to promote successful infection. Another substrate of PKR, the tumor suppressor p53, may be involved in potential PKR regulation of the cell cycle and apoptosis.BIOCARTA
Legacy_Concept_Name	dsRNA_Induction_Pathway
FULL_SYN	dsRNA Induction PathwayPTNCI Double Stranded RNA Induced Gene ExpressionPTBIOCARTA
code	C39224
is someValuesFrom of	nodeID://b668684 nodeID://b678090 nodeID://b680924 nodeID://b683286 nodeID://b688810 nodeID://b688894 nodeID://b695076 nodeID://b695320 nodeID://b700856 nodeID://b706833 nodeID://b712182 nodeID://b718297 nodeID://b720865 nodeID://b721444

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 18 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software