About: Chromatin Remodeling Complex and Coactivator Pathway

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About: Chromatin Remodeling Complex and Coactivator Pathway Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Chromatin Remodeling Complex and Coactivator Pathway
rdfs:subClassOf	Regulatory Pathway
Semantic_Type	Functional Concept
Preferred_Name	Chromatin Remodeling Complex and Coactivator Pathway
UMLS_CUI	C1516510
BioCarta_ID	h_rarrxrPathway
ALT_DEFINITION	RXR and RAR are nuclear receptors that bind either all trans retinoic (tRA) or 9cis retinoic acid (9cisRA). In the absence of ligand corepressors with histone deacetylase activity are bound to the RAR/RXR heterodimer and suppress transcription. Once they bind retinoic acid a conformational change in the receptors cause the dissociation of the corepressors and the binding of coactivators with histone acetylase activity. Following ligand binding by the heterodimer the receptors and proteins in the basal transcription machinery (like TBP and TAF135) are degraded by the proteasome.BIOCARTA
Legacy_Concept_Name	Chromatin_Remodeling_Complex_and_Coactivator_Pathway
FULL_SYN	Chromatin Remodeling Complex and Coactivator PathwayPTNCI Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cellsPTBIOCARTA
code	C39216
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