About: Oocyte Maturation Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Oocyte Maturation Pathway
rdfs:subClassOf	Cell Differentiation or Development Pathway
Semantic_Type	Functional Concept
Preferred_Name	Oocyte Maturation Pathway
UMLS_CUI	C1518585
BioCarta_ID	h_mPRPathway
ALT_DEFINITION	Progesterone (Pg) binds to both intracellular iPR and plasma membrane-bound mPR. After binding to Pg, iPR is recruited to the membrane associated protein tyrosine kinase p60c-src, which induces activation of the MAPK signaling pathway. This results in activation of p90Rsk and the subsequent phosphorylation and inactivation of Myt1, which favors formation of the activated cell cycle complex cyclin B-Cdc2. Activation of cyclin B-Cdc2 causes breakdown of the germinal vesicle and the initiation of oocyte maturation. In contrast, binding of Pg to mPR leads to inhibition of adenylyl cyclase (AC) through activation of Gai or inhibition of Gas. This leads to a decrease in the cAMP-dependent kinase PKA, which relieves inhibition of Cdc25C and also indirectly promotes the activation of MAPK signaling. PKA also regulates the initiation of oocyte maturation through other effects that are independent of PKA activity.BIOCARTA
Legacy_Concept_Name	Oocyte_Maturation_Pathway
FULL_SYN	How Progesterone Initiates the Oocyte MaturationPTBIOCARTA Oocyte Maturation PathwayPTNCI
code	C39156
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