About: Antigen Presentation Pathway

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Antigen Presentation Pathway
rdfs:subClassOf	Immune Response Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	Antigen Presentation Pathway
UMLS_CUI	C1516014
BioCarta_ID	h_mhcPathway
ALT_DEFINITION	Invariant chain (Ii) associates with newly synthesized class II molecules in the endoplasmic reticulum (ER), an interaction that has been shown to interfere with peptide binding to class II molecules. The class II-associated invariant chain peptide (CLIP) region (residues 81-104) of Ii is believed to mediate this inhibition by engaging the binding domain of class II like an antigenic peptide. Together, these findings have given rise to a model in which CLIP association with the class II groove acts to prevent inappropriate presentation of peptides imported into the ER for association with major histocompatibility complex class I molecules.BIOCARTA
Legacy_Concept_Name	Antigen_Presentation_Pathway
FULL_SYN	Antigen Presentation PathwayPTNCI Antigen Processing and PresentationPTBIOCARTA
code	C39153
is someValuesFrom of	nodeID://b641568 nodeID://b641580 nodeID://b653577 nodeID://b678183 nodeID://b678195 nodeID://b678209 nodeID://b678224 nodeID://b678279 nodeID://b678363 nodeID://b678391 nodeID://b685166 nodeID://b704590 nodeID://b717047 nodeID://b717057

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