About: LIS1 Pathway

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	LIS1 Pathway
rdfs:subClassOf	Cell Motility Pathway
Semantic_Type	Functional Concept
Preferred_Name	LIS1 Pathway
UMLS_CUI	C1517693
BioCarta_ID	h_Lis1Pathway
ALT_DEFINITION	LIS1 can bind to MT bundles; however, phospho-LIS1 binding to MT bundles is mediated through the distal zinc finger motif of CLIP-170. When the distal zinc finger motif of CLIP-170 is mutated, the phospho-LIS1 isoform can no longer bind to MT bundles. This can also explain why p150/dynactin is not recruited to the MT bundles. CLIP-170 targets the dynein/dynactin complex to the MT, using phopho-LIS1 as an adapter; the motor complex, being in the proximity of the MT, associates with it. The initial static link to the MT provided by CLIP-170 is released by its hyperphosphorylation and the retrograde dynein/dynactin-dependent movement of the cargo (endocytic vesicle, kinetochore, etc.) takes place. Doublecortin (DCX) is placed close to the LIS1 pathway based on its interaction with LIS1 and its role in microtubule dynamics.BIOCARTA
Legacy_Concept_Name	LIS1_Pathway
FULL_SYN	LIS1 PathwayPTNCI Lissencephaly gene (LIS1) in neuronal migration and developmentPTBIOCARTA
code	C39140
is someValuesFrom of	nodeID://b641615 nodeID://b641641 nodeID://b653932 nodeID://b653952 nodeID://b655219 nodeID://b657786 nodeID://b662040 nodeID://b662068 nodeID://b686172 nodeID://b687305 nodeID://b698660 nodeID://b703376 nodeID://b706843 nodeID://b708490

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