About: G-Protein Signaling Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	G-Protein Signaling Pathway
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	G-Protein Signaling Pathway
UMLS_CUI	C1517335
BioCarta_ID	h_gpcrPathway
ALT_DEFINITION	G-aS-coupled receptors stimulate adenylyl cyclase (AC), which synthesizes cAMP from ATP. In contrast Gai-coupled receptors inhibit AC and so reduce cAMP formation. The bg subunits from Gai and other G proteins are able to activate the MAP kinase pathways and PLCb. GPCRs coupled to the Gaq family of G proteins stimulate PLCb, which cleaves membrane phospholipids to produce IP3, which mobilizes intracellular calcium, and DAG, which activates PKC. Second messenger pathways then activate a range of effector systems to change cell behavior; in many cases this includes the regulation of gene transcription.BIOCARTA
Legacy_Concept_Name	G-Protein_Signaling_Pathway
FULL_SYN	Signaling Pathway from G-Protein FamiliesPTBIOCARTA G-Protein Signaling PathwayPTNCI
code	C39096
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