About: Growth Hormone Signaling Pathway

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About: Growth Hormone Signaling Pathway Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Growth Hormone Signaling Pathway
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	Growth Hormone Signaling Pathway
UMLS_CUI	C1512283
BioCarta_ID	h_ghPathway
ALT_DEFINITION	Growth hormone plays a major role in regulating growth during childhood and adolescence and also regulates metabolism. Defects in growth hormone signaling can result in dwarfism and decreases in growth hormone levels with age have been suggested to play a role in the reduced function of some physiological systems. Growth hormone signals a response in cells through the growth hormone receptor, a member of the cytokine receptor gene family. Growth hormone causes the receptor to dimerize, activating the JAK2 protein kinase. The activity of JAK2 mediates many of the downstream responses to growth hormone through phosphorylation of STAT transcription factors, MAP kinases, other kinase cascades and molecules involved in metabolism like IRS-1. Factors like SOCS and SHP-1 appear to play a role in the down regulation of signaling by growth hormone and cytokines.BIOCARTA
Legacy_Concept_Name	Growth_Hormone_Signaling_Pathway
FULL_SYN	Growth Hormone Signaling PathwayPTNCI Growth Hormone Signaling PathwayPTBIOCARTA
code	C39092
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