About: Formyl Peptide Receptor 1 Signaling Pathway

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About: Formyl Peptide Receptor 1 Signaling Pathway Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Formyl Peptide Receptor 1 Signaling Pathway
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	Formyl Peptide Receptor 1 Signaling Pathway
UMLS_CUI	C1517299
BioCarta_ID	h_fMLPpathway
ALT_DEFINITION	Neutrophils respond to bacterial infection by releasing reactive oxygen species that kill bacteria and by expressing chemokines that attract other immune cells to the site of infection. The multisubunit enzyme NADPH oxidase, expressed by neutrophils, produces reactive oxygen species that are rapidly released in what is known as the respiratory burst. Activity of the NADPH oxidase is induced by fMLP receptor ligands, formylated peptides from bacteria. The fMLP receptor is a G-protein coupled receptor, FPR-1, that activates Map kinase pathways and phospholipase C. Phospholipase C activation releases IP3 and calcium, activating protein kinase C and also activating the transcription factor NFAT, which contributes to activation of chemokine genes. One of the components of the NADPH oxidase is p47phox. PKC activation phosphorylates p47phox to activate NADPH oxidase activity. Activation of Map kinase cascades leads to Erk1/Erk2 dependent p47phox phosphorylation as well as activation of the Elk-1 transcription factor and chemokine gene expression. Inhibition of p38 did not affect p47phox phosphorylation, indicating that p38 is not involved in Erk1/2 activation of the NADPH oxidase. Inhibition of p38 did inhibit NADPH oxidase though, indicating that other pathways contribute to activation of this enzyme.BIOCARTA
Legacy_Concept_Name	Formyl_Peptide_Receptor_1_Signaling_Pathway
FULL_SYN	Formyl Peptide Receptor 1 Signaling PathwayPTNCI fMLP induced chemokine gene expression in HMC-1 cellsPTBIOCARTA
code	C39082
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