About: Erk1/Erk2 MAPK Signaling Pathway

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About: Erk1/Erk2 MAPK Signaling Pathway Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Erk1/Erk2 MAPK Signaling Pathway
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	Erk1/Erk2 MAPK Signaling Pathway
UMLS_CUI	C1516956
BioCarta_ID	h_erkPathway
ALT_DEFINITION	The p44/42 MAP Kinase pathway consists of a protein kinase cascade linking growth and differentiation signals with transcription in the nucleus. Growth factor receptors and tyrosine kinases activate Ras which in turn activates c-Raf, MEK, and MAP kinase. Activated p44/42 MAP Kinase translocates to the nucleus and activates transcription by phosphorylation of kinases such as p90 RSK, MSK, and transcription factors such as ELK-1 and Stat3. The importance of this pathway in both growth control and development has been demonstrated via the transforming properties of various mutant forms of Ras, Raf, and MEK and by their effects on development. Signal amplification and the potential for crosstalk appear to be important features of this regulatory network.BIOCARTA
Legacy_Concept_Name	Erk1_Erk2_MAPK_Signaling_Pathway
FULL_SYN	Erk1/Erk2 Mapk Signaling pathwayPTBIOCARTA Erk1/Erk2 MAPK Signaling PathwayPTNCI
code	C39072
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