About: DR3 and DR4/5 Mediated Apoptosis Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	DR3 and DR4/5 Mediated Apoptosis Pathway
rdfs:subClassOf	Apoptosis Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	DR3 and DR4/5 Mediated Apoptosis Pathway
UMLS_CUI	C1511707
BioCarta_ID	h_deathPathway
ALT_DEFINITION	Apoptosis is specifically induced via signaling through a family of receptors known collectively as 'death receptors' including Fas, TNFR, DR3, -4 and -5. Death receptor ligands characteristically initiate signaling via receptor oligomerization, recruitment of specialized adaptor proteins and activation of caspase cascades. Apo3L recruits initiator caspase 8 via the adapter protein FADD. Caspase 8 then oligomerizes and is activated via autocatalysis. Activated caspase 8 stimulates apoptosis via two parallel cascades: it directly cleaves and activates caspase-3, and it cleaves Bid (a Bcl-2 family protein). Truncated Bid (tBid) translocates to mitochondria, inducing cytochrome C release, which sequentially activates caspases 9 and 3. DR-3L can deliver pro- or anti-apoptotic signals. DR-3 promotes apoptosis via the adaptor proteins TRADD/FADD and the activation of caspase 8. Alternatively, apoptosis is inhibited via an adaptor protein complex including RIP which activates NF-kB and induces survival genes including IAP. Induction of apoptosis via Apo2L requires caspase activity, but the adaptor requirement is unclear.BIOCARTA
Legacy_Concept_Name	DR3_and_DR4_5_Mediated_Apoptosis_Pathway
FULL_SYN	Induction of apoptosis through DR3 and DR4/5 Death ReceptorsPTBIOCARTA DR3 and DR4/5 Mediated Apoptosis PathwayPTNCI
code	C39049
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