About: D4-GDI Signaling Pathway

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About: D4-GDI Signaling Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	D4-GDI Signaling Pathway
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	D4-GDI Signaling Pathway
UMLS_CUI	C1511643
BioCarta_ID	h_d4gdiPathway
ALT_DEFINITION	D4-GDP dissociation inhibitor (D4-GDI) is a negative regulator of the ras related Rho Family of GTPases. Since the rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28 kDa mature form of D4-GDI to give a 5 kDa and 23 kDa size fragment. The 23 kDa fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-Terminal kinase, a regulator of apoptosis, may be one of the mechanisms.BIOCARTA
Legacy_Concept_Name	D4-GDI_Signaling_Pathway
FULL_SYN	D4-GDI Signaling PathwayPTNCI D4-GDI Signaling PathwayPTBIOCARTA
code	C39045
is someValuesFrom of	nodeID://b642815 nodeID://b643062 nodeID://b646483 nodeID://b652414 nodeID://b652431 nodeID://b652463 nodeID://b652562 nodeID://b652591 nodeID://b657826 nodeID://b657840 nodeID://b657877 nodeID://b657973 nodeID://b658002 nodeID://b684644 nodeID://b684736 nodeID://b700465 nodeID://b702324 nodeID://b709149

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