About: CSK Protein Kinase Activation Pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: CSK Protein Kinase Activation Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	CSK Protein Kinase Activation Pathway
rdfs:subClassOf	Immune Response Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	CSK Protein Kinase Activation Pathway
UMLS_CUI	C1511457
BioCarta_ID	h_CSKPathway
ALT_DEFINITION	Interaction of T cell receptor with specific antigen in the context of MHC II activates a signal transduction pathway that leads to T cell activation. In the T cell receptor signaling pathway, the src family kinases Lck and Fyn are activated to phosphorylate proteins in the T cell receptor complex which recruit and activate the ZAP70 kinase. The activation of ZAP70 phosphorylates downstream targets that activate MAP kinase pathways and cause T cell activation. The CD45 phosphorylase also plays a role in T cell receptor signaling, dephosphorylated Lck and Fyn to activate them. Other factors modulate T cell receptor activation. Csk (COOH-terminal Src kinase) phosphorylates Lck and deactivates it, opposing the action of CD45. The phosphorylation of Lck by Csk inhibits T cell receptor signaling and inhibits T cell activation. Csk activity is regulated in T cells by PKA, the cAMP-dependent protein kinase activated by the second messenger cAMP. The activity of Csk also appears to depend on other factors such as CBP, which recruits Csk to the plasma membrane in lipid rafts where other signaling factors such the T cell receptor complex are localized. CBP also directly activates Csk.BIOCARTA
Legacy_Concept_Name	CSK_Protein_Kinase_Activation_Pathway
FULL_SYN	Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell ReceptorPTBIOCARTA CSK Protein Kinase Activation PathwayPTNCI
code	C39038
is someValuesFrom of	nodeID://b653304 nodeID://b653335 nodeID://b653362 nodeID://b653387 nodeID://b653489 nodeID://b653511 nodeID://b654791 nodeID://b654832 nodeID://b655162 nodeID://b655177 nodeID://b674824 nodeID://b675365 nodeID://b675390 nodeID://b677790 nodeID://b678283 nodeID://b678367 nodeID://b685740 nodeID://b700557 nodeID://b700605 nodeID://b700658 nodeID://b701342 nodeID://b704974 nodeID://b705024 nodeID://b705623 nodeID://b716698 nodeID://b716730 nodeID://b716757 nodeID://b716830 nodeID://b725735 nodeID://b726413

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 18 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software