About: MAP Kinase Downregulation Pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: MAP Kinase Downregulation Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	MAP Kinase Downregulation Pathway
rdfs:subClassOf	Regulatory Pathway
Semantic_Type	Functional Concept
Preferred_Name	MAP Kinase Downregulation Pathway
UMLS_CUI	C1518105
BioCarta_ID	h_cdk5Pathway
ALT_DEFINITION	Map kinases transduce responses to extracellular signals by a variety of routes, and communicate with other pathways through extensive crosstalk networks. A closely studied Map kinase cascade originates with tyrosine kinase activation, and activation of Ras. Ras activates Raf, Raf activates the Map kinase kinases Mek1 and Mek2 and these kinases activate downstream Map kinases like Erk1 and Erk2. Erk1 and Erk2 in turn activate transgenes like p35 through the Map kinase activated transcription factor EGR-1. Mek1 plays a central role in many different Map kinase pathways. Factors that activate Mek1 include growth factors like NGF, cytokines, chemokines, and phorbol ester, resulting in cellular proliferation and survival. Mek1 activation may also play a role in differentiation in neuronal tissues. In cultured neuronal PC-12 cells, NGF induces neurite outgrowth via Mek1 and the map kinase pathway. Constitutive activation of Mek1 can transform cells and may play a role in cancer. The crucial role of Mek1 in a variety of pathways including cellular transformation suggests that the cell must tightly regulate its activity. Cdk5 is a kinase that regulates the activity of Mek1. Although Cdk5 is a member of the cyclin-dependent kinase gene family, the activity of Cdk5 does not appear to be regulated by cyclins, but is activated by association with p35. Cdk5 does not act as a checkpoint kinase to regulate cell cycle progression, but acts as a regulatory kinase involved in other post-mitotic processes such as neuronal activity such as neuronal migration during development and neurite outgrowth. Mice lacking Cdk5 exhibit defects in neuronal development. One target of Cdk5 is Mek1. Phosphorylation of Mek1 by Cdk5 represses Mek1 activity and blocks downstream cellular responses. The activation of p35 by Map kinase pathways followed by deactivation of Map kinase signaling by the Cdk5/p35 complex completes the loop of a feedback circuit to terminate Map kinase signaling.BIOCARTA
Legacy_Concept_Name	MAP_Kinase_Downregulation_Pathway
FULL_SYN	MAP Kinase Downregulation PathwayPTNCI Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathwayPTBIOCARTA
code	C39022
is someValuesFrom of	nodeID://b653934 nodeID://b653953 nodeID://b662041 nodeID://b662070 nodeID://b668640 nodeID://b669781 nodeID://b678909 nodeID://b688338 nodeID://b688600 nodeID://b688685 nodeID://b689092 nodeID://b689194 nodeID://b693282 nodeID://b695345 nodeID://b695354 nodeID://b696262 nodeID://b696276 nodeID://b706314 nodeID://b706365 nodeID://b726321

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 18 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software