About: Bystander B Cell Activation Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Bystander B Cell Activation Pathway
rdfs:subClassOf	Immune Response Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	Bystander B Cell Activation Pathway
UMLS_CUI	C1511352
BioCarta_ID	h_bbcellPathway
ALT_DEFINITION	Expression of Fas-Ligand by T cells can induce apoptosis through interaction with Fas on the target cell. A target of Fas-mediated apoptosis is the B cell. B cells that are not activated by antigen, bystander B cells, can interact through CD40 with the CD40 ligand on T cells. The CD40-CD40L interaction induces Fas expression by bystander B cells, and the interaction of Fas with the T cell Fas-Ligand, followed by B cell apoptosis. B cells that are activated by antigen binding and that interact with the T cell receptor through the B cell MHC II appear to become resistant to Fas-mediated apoptosis, survive and proliferate. IL-4 also appears to confer B cell resistance to Fas-mediated apoptosis. The induction of apoptosis in non-antigen stimulated B cells may prevent B cells from proliferating inappropriately and failure of this mechanism may be involved in autoimmune disorders and B cell lymphomas.BIOCARTA
Legacy_Concept_Name	Bystander_B_Cell_Activation_Pathway
FULL_SYN	Bystander B Cell Activation PathwayPTNCI Bystander B Cell ActivationPTBIOCARTA
code	C39003
is someValuesFrom of	nodeID://b653206 nodeID://b653220 nodeID://b653424 nodeID://b653439 nodeID://b653488 nodeID://b653510 nodeID://b671942 nodeID://b671964 nodeID://b717967 nodeID://b717980 nodeID://b718032 nodeID://b718044

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