About: BARD1 Pathway

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	BARD1 Pathway
rdfs:subClassOf	DNA Repair Pathway
Semantic_Type	Functional Concept
Preferred_Name	BARD1 Pathway
UMLS_CUI	C1516117
BioCarta_ID	h_bard1Pathway
ALT_DEFINITION	BRCA1 is a breast and ovarian cancer tumor suppressor protein that associates with BARD1 to form a RING/RING heterodimer. The BRCA1/BARD1 RING complex functions as an ubiquitin (Ub) ligase with activity substantially greater than individual BRCA1 or BARD1 subunits. The BRCA1 tumor suppressor forms a heterodimer with the BARD1 protein, and the resulting complex functions as an E3 ubiquitin ligase that catalyzes the synthesis of polyubiquitin chains. UbcH5c and UbcH7 also interact with the BRCA1/BARD1 complex with similar affinity (not shown on this figure). Although the in vivo substrate(s) is not yet known, BRCA1 has been observed to undergo autoubiquitination and is capable of monoubiquitinating histones 2A and 2AX in vitro.BIOCARTA
Legacy_Concept_Name	BARD1_Pathway
FULL_SYN	BARD1 PathwayPTNCI BRCA1-dependent Ub-ligase activityPTBIOCARTA
code	C38999
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