About: ATM Signaling Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	ATM Signaling Pathway
rdfs:subClassOf	Signaling Pathway DNA Repair Pathway
Semantic_Type	Functional Concept
Preferred_Name	ATM Signaling Pathway
UMLS_CUI	C1510698
BioCarta_ID	h_atmPathway
ALT_DEFINITION	The ataxia telangiectasia-mutated gene (ATM) encodes a protein kinase that acts as a tumor suppressor. ATM activation by ionizing radiation damage to DNA stimulates DNA repair and blocks progression through the cell cycle. Mutation of the ATM gene causes the disease ataxia telangiectasia which involves an inherited predisposition to some cancers. To play this role ATM interacts with a broad network of proteins, including checkpoint factors (chk1, chk2), tumor suppressors (p53 and BRCA), DNA repair factors (RAD50, RAD51, GADD45), and other signaling molecules (c-Abl and NF-kB). In addition to regulating DNA repair and the cell cycle, ATM can also trigger apoptosis in radiation treated cells.BIOCARTA
Legacy_Concept_Name	ATM_Signaling_Pathway
FULL_SYN	ATM Signaling PathwayPTBIOCARTA ATM Signaling PathwayPTNCI
code	C38996
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