About: GM-CSF Receptor     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • GM-CSF Receptor
rdfs:subClassOf
Semantic_Type
  • Receptor
Preferred_Name
  • GM-CSF Receptor
UMLS_CUI
  • C0080091
Legacy_Concept_Name
  • GM-CSF_Receptor
FULL_SYN
  • GM-CSF ReceptorPTNCI
  • CSF2RA/CSF2RB ComplexSYNCI
  • CSF2RA/CSF2RB ReceptorSYNCI
DEFINITION
  • Heterodimeric human GM-CSF Receptor is composed of Colony Stimulating Factor 2 Receptor Alpha Chain and Colony Stimulating Factor 2 Receptor Beta Chain. CSF2RA is a type I membrane protein with a box 1 motif for JAK interaction/activation and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. The receptor signal transducing beta chain is common to the high affinity IL3-, IL5- and GM-CSF receptors. CSF2R transduces the CSF2 signal for proliferation, differentiation, and activation of (primarily) granulocyte and macrophage hematopoietic cells. (NCI)NCI
code
  • C38991
sameAs
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