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AttributesValues
rdf:type
rdfs:label
  • Double Stranded RNA Biosynthesis Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • Double Stranded RNA Biosynthesis Pathway
UMLS_CUI
  • C1514665
BioCarta_ID
  • h_antisensePathway
ALT_DEFINITION
  • About 8% of human genes have been estimated to carry out transcription from both DNA strands, resulting in significant level of endogenous antisense RNA. In the cytoplasm the antisense RNA leads to formation of long dsRNA, which activates the interferon and RNA-dependent protein kinase antiviral pathway. Most endogenous antisense RNA is made in the nucleus and two responses have been suggested for the nuclear dsRNA. First, the dsRNA may be processed by enzymes of the family of adenosine deaminases that act on RNA (ADAR). The deaminated dsRNAs contain various levels of inosines. dsRNA containing high level of inosines are tightly bound by a protein complex that results in their nuclear retention. dsRNA containing low level of inosines may be able to exit the nucleus. Second, the nuclear dsRNA can lead to gene silencing and heterochromatin formation.BIOCARTA
Legacy_Concept_Name
  • RNA_Interference_Pathway
FULL_SYN
  • Antisense PathwayPTBIOCARTA
  • RNA Interference PathwaySYNCI
  • dsRNA Biosynthesis PathwaySYNCI
  • Double Stranded RNA Biosynthesis PathwayPTNCI
code
  • C38987
is someValuesFrom of
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