About: AHR Signal Transduction Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	AHR Signal Transduction Pathway
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	AHR Signal Transduction Pathway
UMLS_CUI	C1510689
BioCarta_ID	h_acrPathway
ALT_DEFINITION	The Ah receptor, bHLH/PAS transcription factor, upon binding of an agonist such as 2,3,7,8-tetrachlorodibenzo-p-dioxin translocates into the nucleus and heterodimerizes with the transcription factor ARNT. The Ah receptor/ARNT heterodimer binds to dioxin-responsive elements and alters expression of a number of genes including; CYP1A1, CYP1A2, CYP1B1, and NAD(P)H quinone oxidoreductase. The inactive form of the Ah receptor exists in the cytoplasm as a tetrameric complex composed of the ligand binding subunit, a dimer of the 90-kDa heat shock protein, and X-associated protein 2 (also referred to as AIP or ARA9).BIOCARTA
Legacy_Concept_Name	AHR_Signal_Transduction_Pathway
FULL_SYN	Ahr Signal Transduction PathwayPTBIOCARTA AHR Signal Transduction PathwayPTNCI
code	C38972
is someValuesFrom of	nodeID://b642176 nodeID://b642181 nodeID://b642236 nodeID://b643147 nodeID://b646693 nodeID://b646700 nodeID://b678976 nodeID://b679314

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