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AttributesValues
rdf:type
rdfs:label
  • Mucin-1
equivalentClass
OMIM_Number
  • 158340
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Mucin-1
UMLS_CUI
  • C1513706
Legacy_Concept_Name
  • Mucin-1
FULL_SYN
  • DF3 AntigenSYNCI
  • EMASYNCI
  • PEMSYNCI
  • PUMSYNCI
  • MUC1SYNCI
  • CD227SYNCI
  • MUC-1SYNCI
  • Polymorphic Epithelial MucinSYNCI
  • Cancer Antigen 15-3SYNCI
  • EpisialinSYNCI
  • H23 AntigenSYNCI
  • Tumor-Associated MucinSYNCI
  • CD227 AntigenSYNCI
  • Tumor-Associated Epithelial Membrane AntigenSYNCI
  • Carcinoma-Associated MucinSYNCI
  • PEMTSYNCI
  • Epithelial Membrane AntigenSYNCI
  • H23AGSYNCI
  • MucinSYNCI
  • Breast Carcinoma-Associated Antigen DF3SYNCI
  • CA 15-3SYNCI
  • Mucin 1SYNCI
  • Mucin-1PTNCI
  • Peanut-Reactive Urinary MucinSYNCI
  • CA 27-29SYNCI
  • CA 27.29SYNCI
  • Cancer Antigen 27.29SYNCI
  • Transmembrane Mucin 1SYNCI
Swiss_Prot
  • P15941
Gene_Encodes_Product
  • NM_002456
DEFINITION
  • Mucin-1 (1255 aa, ~122 kDa) is encoded by the human MUC1 gene. This protein plays a role in both signaling and cell adhesion.NCI
DesignNote
  • Mucin-1 is a type I membrane protein (major form) containing a large extracellular tandem repeat domain and a SEA domain. The number of repeats is highly polymorphic. This protein is expressed as at least 10 isoforms produced by alternative splicing. Isoforms 5 and 9 are secreted. Isoform 7 behaves as a receptor and binds isoform 5; binding induces phosphorylation of isoform 7, alters cell morphology, and initiates cell signaling. Cleaved isoform 1 forms a heterodimer with its secreted C-terminal peptide. Isoforms 1 and 7 are transphosphorylated on serine and tyrosine residues.
code
  • C38967
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