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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Elongation Factor 1
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Elongation Factor 1
UMLS_CUI
  • C0059036
Legacy_Concept_Name
  • Elongation_Factor-1
FULL_SYN
  • Eukaryotic Translation Elongation Factor 1SYNCI
  • E-F1SYNCI
  • Elongation Factor 1PTNCI
DEFINITION
  • Heterotrimeric Elongation Factor 1 (containing alpha/beta/gamma or alpha/delta/gamma subunits) is responsible for delivery of aminoacyl tRNAs to the ribosome. Containing domains that bind guanine nucleotides, 80S ribosomes, and aminoacyl-tRNAs, the alpha EF-1 subunit interacts with beta/delta subunits and mediates delivery and GTP-dependent binding of aminoacyl-tRNAs to the 80S ribosome A-site. Homologous beta and delta subunits (guanine nucleotide exchange factors) stimulate GDP/GTP exchange bound to EF-1-alpha; phosphorylation affects the GDP/GTP exchange rate. The conserved gamma subunit contains an EEF1G domain and an N-terminal GST domain that may be involved in regulating EF-1 multisubunit assembly and anchorage to other cellular components. (NCI)NCI
code
  • C38958
sameAs
http://linked.open...y/mesh/hasConcept
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