About: Integrin Beta-3     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Integrin Beta-3
rdfs:subClassOf
equivalentClass
OMIM_Number
  • 173470
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Integrin Beta-3
UMLS_CUI
  • C0638262
Legacy_Concept_Name
  • Integrin_Beta-3
FULL_SYN
  • CD61 AntigenSYNCI
  • Antigen CD61SYNCI
  • Platelet Membrane Glycoprotein IIIaSYNCI
  • Integrin Beta Chain Beta 3SYNCI
  • Integrin Beta-3PTNCI
  • Platelet Glycoprotein IIIaSYNCI
  • CD61SYNCI
  • GP3ASYNCI
  • ITGB3SYNCI
  • GPIIIaSYNCI
Swiss_Prot
  • P05106
DEFINITION
  • Integrin beta-3 (788 aa, 87 kD) is a cell adhesion process protein that is encoded by the human ITGB3 gene and has roles in cell adhesion and blood coagulation.NCI
DesignNote
  • Widely expressed by human ITGB3 Gene (ITGB Family), type I membrane protein Integrin Beta 3 contains a VWFA-like domain and is involved in cell adhesion and signaling. Multiple heterodimeric alpha/beta combinations result in different integrins. ITGB3 associates with alphaIIB or alphaV and recognize RGD; aIIB/beta-3 also recognizes HHLGGGAKQAGDV in FN gamma. Beta-3C interacts with FLNB. aV/beta-3 is a receptor for cytotactin, fibronectin, laminin, MMP-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin, and von Willebrand factor. Receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin, and vitronectin, aIIB/beta-3 binds fibrinogen to induce platelet aggregation and plug ruptured endothelia. In response to platelet aggregation, Tyr-773/785 phosphorylated ITGB3 appears to bind GRB2/SHC. ITGB3 defects cause Glanzmann thrombasthenia (GT).
code
  • C38955
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