About: Interleukin 12 Receptor     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Interleukin 12 Receptor
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Receptor
Preferred_Name
  • Interleukin 12 Receptor
UMLS_CUI
  • C0255732
Legacy_Concept_Name
  • Interleukin-12_Receptor
FULL_SYN
  • Interleukin 12 ReceptorPTNCI
  • Interleukin 12 ReceptorSYNCI
  • High Affinity Interleukin 12 ReceptorSYNCI
  • Interleukin 12 Receptor BetaSYNCI
  • High Affinity Interleukin 12 Receptor BetaSYNCI
DEFINITION
  • Human high affinity Interleukin 12 Receptor Beta (Type I Cytokine Receptor 2 Family) is composed of Interleukin 12 Receptor Beta 1 Chain (IL12RB1 Gene) and Interleukin 12 Receptor Beta 2 Chain (IL12RB2 Gene), both type I transmembrane proteins involved in signal transduction and each containing 5 FNIII domains; a box 1 motif required for JAK interaction/activation; and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. IL12RB1/2 activity appears to contribute to host defense mechanisms and the inflammatory response. Both IL12RB1 oligomers and IL12RB2 oligomers act as a low affinity IL12 receptor. (NCI)NCI
  • Human high affinity Interleukin 12 Receptor is composed of Interleukin 12 Receptor Beta 1 Chain (I12RB1) and Interleukin 12 Receptor Beta 2 Chain (IL12RB2), each a type I transmembrane disulfide-linked dimer/oligomer protein containing 5 FNIII domains, a box 1 motif required for JAK interaction/activation, and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. Involved in IL12 signal transduction, IL12RB1 and IL12RB2 oligomers act as low affinity IL12 receptors. (NCI)NCI
code
  • C38915
sameAs
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