About: CD19 Antigen     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • CD19 Antigen
equivalentClass
OMIM_Number
  • 107265
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • CD19 Antigen
UMLS_CUI
  • C0108748
Legacy_Concept_Name
  • CD19_Antigen
FULL_SYN
  • CD19 AntigenPTNCI
  • CD19 AntigenSYNCITCGA
  • B-Lymphocyte Antigen CD19SYNCI
  • B4SYNCI
  • CD19SYNCI
  • Differentiation Antigen CD19SYNCI
  • Leu-12SYNCI
  • B-Lymphocyte Surface Antigen B4SYNCI
Swiss_Prot
  • P15391
DEFINITION
  • Expressed on early B-cells by human CD19 Gene (Ig Superfamily), 95-kDa CD19_Antigen is a type I cell surface protein with 2 extracellular IgC2 domains, a cytoplasmic tail with 9 conserved Tyr residues, and no significant homology with other known proteins. Assembled with BCR, CD19 decreases the threshold for antigen receptor-dependent stimulation of B lymphocyte proliferation and intersects with many intracellular signaling pathways. CD19 functions as an adaptor protein for Src family kinase amplification, crucial for antigen receptor-induced signal transduction. Following BCR/CD19 ligation, LYN (Src kinase) phosphorylates CD19-Y513, binds to the CD19-SH2 domain and phosphorylates CD19-Y482. CD19-pY482 recruits more LYN, leading to LYN phosphorylation and CD19-Y391 phosphorylation. CD19-pY391 recruits VAV, phosphorylated by LYN. (NCI)NCI
code
  • C38894
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