About: Focal Adhesion Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Focal Adhesion Pathway
rdfs:subClassOf	Cell Motility Pathway
Semantic_Type	Functional Concept
Preferred_Name	Focal Adhesion Pathway
UMLS_CUI	C1512810
KEGG_ID	hsa04510
ALT_DEFINITION	Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signaling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signaling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signaling.KEGG
Legacy_Concept_Name	Integrin-mediated_Cell_Adhesion_Pathway
FULL_SYN	Focal Adhesion PathwayPTNCI Focal AdhesionPTKEGG Integrin-mediated Cell Adhesion PathwaySYNCI Integrin-mediated Cell AdhesionSYKEGG
code	C38829
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