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AttributesValues
rdf:type
rdfs:label
  • Cell Cycle Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • Cell Cycle Pathway
NCI_META_CUI
  • CL322969
KEGG_ID
  • hsa04110
ALT_DEFINITION
  • Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.KEGG
Legacy_Concept_Name
  • Cell_Cycle_Pathway
FULL_SYN
  • Cell CyclePTKEGG
  • Cell Cycle PathwayPTNCI
code
  • C38794
is someValuesFrom of
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