About: Apoptosis Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Apoptosis Pathway
rdfs:subClassOf	Apoptosis Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	Apoptosis Pathway
NCI_META_CUI	CL322961
KEGG_ID	hsa04210
ALT_DEFINITION	Apoptosis is a genetically controlled mechanism of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily members and ligands) and the intrinsic (mitochondria-associated) pathways, both of which are found in the cytoplasm. The extrinsic pathway is triggered by death receptor engagement, which initiates a signaling cascade mediated by caspase-8 activation. Caspase-8 both feeds directly into caspase-3 activation and stimulates the release of cytochrome c by the mitochondria. Caspase-3 activation leads to the degradation of cellular proteins necessary to maintain cell survival and integrity. The intrinsic pathway occurs when various apoptotic stimuli trigger the release of cytochrome c from the mitochondria (independently of caspase-8 activation). Cytochrome c interacts with Apaf-1 and caspase-9 to promote the activation of caspase-3. Recent studies point to the ER as a third subcellular compartment implicated in apoptotic execution. Alterations in Ca2+ homeostasis and accumulation of misfolded proteins in the ER cause ER stress. Prolonged ER stress can result in the activation of BAD and/or caspase-12, and execute apoptosis.KEGG
Legacy_Concept_Name	Apoptosis_Pathway
FULL_SYN	Apoptosis PathwayPTNCI ApoptosisPTKEGG
code	C38784
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