About: Amyotrophic Lateral Sclerosis Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Amyotrophic Lateral Sclerosis Pathway
rdfs:subClassOf	Neurodegenerative Disorders Pathway
Semantic_Type	Functional Concept
Preferred_Name	Amyotrophic Lateral Sclerosis Pathway
UMLS_CUI	C1521995
KEGG_ID	hsa05014
ALT_DEFINITION	Amyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord, leading to paralysis of voluntary muscles. Mutant superoxide dismutase 1 (SOD1), as seen in some familial amyotrophic lateral sclerosis (FALS) cases, may be toxic because it is unstable, forming aggregates in the motor neuron cytoplasm, axoplasm and mitochondria. Within mitochondria, mutant SOD1 may interfere with the anti-apoptotic function of Bcl-2, affect mitochondrial import by interfering with the translocation machinery (TOM/TIM), and generate toxic free radicals (ROS) via aberrant superoxide chemistry. These changes may then result in abnormal mitochondrial energy metabolism, Ca2+ handling, and release of pro-apoptotic factors. Reactive oxygen species (ROS), produced within mitochondria, inhibit the function of EAAT2, the main glial glutamate transporter protein, responsible for most of the reuptake of synaptically released glutamate. Glutamate excess causes neurotoxicity by increasing intracellular calcium, which enhances oxidative stress and mitochondrial damage. Mutant SOD1 can also trigger oxidative reactions by various means including by increasing levels of peroxynitrite, which can then cause damage through the formation of hydroxyl radicals or via nitration of tyrosine residues on proteins. Nitration may target neurofilament proteins, disrupting their phosphorylation and affecting axonal transport. Collectively, these mechanisms (or a combination thereof) are predicted to disturb cellular homeostasis (within glial and/or motor neurons), ultimately triggering motor neuron death.KEGG
Legacy_Concept_Name	Amyotrophic_Lateral_Sclerosis_Pathway
FULL_SYN	Amyotrophic Lateral Sclerosis (ALS)PTKEGG Amyotrophic Lateral Sclerosis PathwayPTNCI
DesignNote	This pathway originally was KEGG_ID hsa05030.
code	C38782
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