About: Alzheimer's Disease Pathway KEGG

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Attributes	Values
rdf:type	Class
rdfs:label	Alzheimer's Disease Pathway KEGG
rdfs:subClassOf	Neurodegenerative Disorders Pathway
Semantic_Type	Functional Concept
Preferred_Name	Alzheimer's Disease Pathway KEGG
UMLS_CUI	C1521724
KEGG_ID	hsa05010
ALT_DEFINITION	Alzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. The extracellular Abeta oligomers may activate caspases through activation of cell surface death receptors. Alternatively, intracellular Abeta may contribute to pathology by facilitating tau hyper-phosphorylation, disrupting mitochondria function, and triggering calcium dysfunction. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specifically the more amyloidogenic form, Abeta42. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.KEGG
Legacy_Concept_Name	Alzheimers_Disease_Pathway
FULL_SYN	Alzheimer's DiseasePTKEGG Alzheimer's Disease Pathway KEGGPTNCI
code	C38778
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