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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Valerian
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Valerian
UMLS_CUI
  • C0795675
In_Clinical_Trial_For
  • Cancer-related sleep disorders
FDA_UNII_Code
  • JWF5YAW3QW
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 350071
PDQ_Closed_Trial_Search_ID
  • 350071
Legacy_Concept_Name
  • Valeriana_Officinalis_Extract
FULL_SYN
  • VALERIANPTFDAJWF5YAW3QW
  • Valeriana Officinalis ExtractSYNCI
  • ValerianPTNCI
DEFINITION
  • An herbal extract isolated from the root of the plant Valeriana officinalis with sedative and anxiolytic activities. Valeriana officinalis extract contains four distinct classes of phytochemical constituents: volatile oils; sesquiterpenoids, including valerenic acid and its hydroxyl and acetoxyl derivative; valepotriates; and volatile pyridine alkaloids. Although the exact mechanism of action has not been established, the sesquiterpenoids in Valeriana officinalis extract, particularly valerenic acid, appear to account for its sedative and anxiolytic effects. Valerenic acid is both a subtype-selective GABA-A receptor agonist and a 5HT-5A receptor partial agonist. The sedative-hypnotic benzodiazepines are GABA-A receptor agonists.NCI
code
  • C38725
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