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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Anakinra
rdfs:subClassOf
Concept_In_Subset
Is_Related_To_Endogenous_Product
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Anakinra
UMLS_CUI
  • C0245109
CAS_Registry
  • 143090-92-0
Accepted_Therapeutic_Use_For
  • Rheumatoid arthritis
In_Clinical_Trial_For
  • Metastatic cancer expressing IL-1 gene
FDA_UNII_Code
  • 9013DUQ28K
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is used to treat rheumatoid arthritis, and is being studied in the treatment of cancer. Anakinra blocks the action of interleukin 1 (IL-1). It is a type of interleukin receptor antagonist.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43007
PDQ_Closed_Trial_Search_ID
  • 43007
Legacy_Concept_Name
  • Anakinra
FULL_SYN
  • ANAKINRAPTFDA9013DUQ28K
  • rIL1RNABNCI
  • KinaretPTNCI-GLOSSCDR0000347382
  • rIL-1raABNCI
  • KineretBRNCI
  • anakinraPTNCI-GLOSSCDR0000346487
  • AnakinraPTNCI
DEFINITION
  • A recombinant human nonglycosylated interleukin-1 (IL-1) receptor antagonist with potential antineoplastic activity. Anakinra binds to the IL-1 receptor, thereby blocking the binding of the IL-1 to and activation of its receptor. Blockade of IL-1 activity may inhibit the cascade of downstream pro-angiogenic factors such as vascular endothelial cell growth factor, tumor necrosis factor-alpha, and IL-6, resulting in inhibition of tumor angiogenesis. (NCI04)NCI
code
  • C38717
sameAs
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