About: Amsilarotene     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Amsilarotene
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Amsilarotene
UMLS_CUI
  • C0675838
CAS_Registry
  • 125973-56-0
In_Clinical_Trial_For
  • Advanced hepatocellular carcinoma
FDA_UNII_Code
  • Q1418F39MH
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called synthetic retinoids and angiogenesis inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 350384
PDQ_Closed_Trial_Search_ID
  • 350384
Chemical_Formula
  • C20H27NO3Si2
Legacy_Concept_Name
  • TAC-101
FULL_SYN
  • AMSILAROTENEPTFDAQ1418F39MH
  • AmsilarotenePTNCI
  • TAC-101PTNCI-GLOSSCDR0000367448
  • TAC 101CNNCI
  • TAC-101CNNCI
DEFINITION
  • A retinobenzoic acid with potential antineoplastic activity. Amsilarotene inhibits retinoblastoma-gene product (RB) phosphorylation and increases the presence of 2 cyclin-dependent kinase (CDK) inhibitors, resulting in cell cycle arrest. This agent also causes a cytotoxic decline in cyclin A and thymidylate synthase expression.NCI
code
  • C38684
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