About: Nitric Oxide Synthase 2B     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:DeprecatedClass, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Nitric Oxide Synthase 2B
rdfs:subClassOf
OMIM_Number
  • 600719
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Enzyme
Preferred_Name
  • Nitric Oxide Synthase 2B
OLD_PARENT
  • Nitric_Oxide_Synthetase
OLD_ROLE
  • Gene_Product_Plays_Role_In_Biological_Process some 'Immune Cell Activation Process'
  • Gene_Product_Plays_Role_In_Biological_Process some 'Intercellular Communication Process'
  • Gene_Product_Encoded_By_Gene some 'NOS2B Gene'
  • Gene_Product_Plays_Role_In_Biological_Process some Oxidation/Reduction
  • Gene_Product_Plays_Role_In_Biological_Process some 'Cell-Mediated Cytotoxicity'
  • Gene_Product_Has_Biochemical_Function some Oxidoreductase
UMLS_CUI
  • C1518334
Concept_Status
  • Retired_Concept
Legacy_Concept_Name
  • Nitric_Oxide_Synthase-2B
FULL_SYN
  • NOS Type IIBSYNCI
  • Nitric Oxide Synthase 2BPTNCI
  • Nitric Oxide Synthase IIBSYNCI
  • NOS2BSYNCI
  • NOSIIBSYNCI
Swiss_Prot
  • P81272
DEFINITION
  • Encoded by human NOS2B Gene (NOS Family), calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 2B binds FAD and FMN cofactors, requires BH4 which may stabilize the dimer, and synthesizes reactive free radical nitric oxide messenger (from L-arginine). NO has antimicrobial and antitumoral activities in macrophages. NOS2B may bind SLC9A3R1. IL12 requires NOS2 to stimulate NK cell cytotoxicity and to activate STAT4 tyrosine-phosphorylation by TYK2 in innate immunity. (NCI)NCI
DesignNote
  • Wed Sep 26 15:23:14 EDT 2012 - P81272 has been designated Obsolete and deleted by UniProtKB/Swiss-Prot. The NOS2B gene is a pseudogene. No protein is encoded.
code
  • C38567
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