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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Clotrimazole
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Clotrimazole
NSC_Code
  • 257473
UMLS_CUI
  • C0009074
CAS_Registry
  • 23593-75-1
FDA_UNII_Code
  • G07GZ97H65
Contributing_Source
  • FDA
ALT_DEFINITION
  • An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 39116
PDQ_Closed_Trial_Search_ID
  • 39116
Chemical_Formula
  • C22H17ClN2
Legacy_Concept_Name
  • Clotrimazole
CHEBI_ID
  • CHEBI:3764
FULL_SYN
  • CLOTRIMAZOLEPTFDAG07GZ97H65
  • ClotrimazolePTNCI
  • Gyne-LotriminBRNCI
  • Mycelex TrocheBRNCI
  • CLOTABNCI
  • 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazoleSNNCI
  • ClotrimazolePTDCP05194
  • MycelexBRNCI
  • LotriminBRNCI
DEFINITION
  • A synthetic, imidazole derivate with broad-spectrum, antifungal activity. Clotrimazole inhibits biosynthesis of sterols, particularly ergosterol, an essential component of the fungal cell membrane, thereby damaging and affecting the permeability of the cell membrane. This results in leakage and loss of essential intracellular compounds, and eventually causes cell lysis.NCI
code
  • C381
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