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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Tesetaxel
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Tesetaxel
UMLS_CUI
  • C1313820
CAS_Registry
  • 333754-36-2
In_Clinical_Trial_For
  • Colorectal adenocarcinoma; unspecified solid tumor
FDA_UNII_Code
  • UG97LO5M8Y
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of cancer. It is a type of taxane derivative.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 346914
PDQ_Closed_Trial_Search_ID
  • 346914
Chemical_Formula
  • C46H60FN3O13
Legacy_Concept_Name
  • DJ-927
FULL_SYN
  • DJ-927PTNCI-GLOSSCDR0000367408
  • DJ-927CNNCI
  • TESETAXELPTFDAUG97LO5M8Y
  • TesetaxelPTNCI
DEFINITION
  • A semi-synthetic, orally bioavailable taxane derivative with potential antineoplastic and antiangiogenic properties. Tesetaxel binds to and stabilizes tubulin, promoting microtubule assembly and thereby preventing microtubule depolymerization. This may lead to cell cycle arrest and an inhibition of cell proliferation. This agent may also inhibit pro-angiogenic factors such as vascular endothelial growth factor (VEGF). As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors.NCI
code
  • C37451
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