About: Interferon Gamma Receptor Complex     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Interferon Gamma Receptor Complex
rdfs:subClassOf
Semantic_Type
  • Receptor
Preferred_Name
  • Interferon Gamma Receptor Complex
UMLS_CUI
  • C1334197
Legacy_Concept_Name
  • Interferon_Gamma_Receptor_Complex
FULL_SYN
  • Interferon Gamma Receptor ComplexPTNCI
  • IFN-Gamma ReceptorSYNCI
DEFINITION
  • Expressed in monocytes, lymphocytes, and placenta, human Interferon Gamma Receptor Complex (Type II Cytokine Family Receptor) is a Ser/Thr phosphorylated type I membrane protein heteromeric receptor for IFN-gamma, composed of IFNGR1 and IFNGR2, that activates macrophages in host defenses. In mediating innate immune responses to viral infection, binding of IFN-gamma activates JAK kinases leading to tyrosine phosphorylation of STAT1 and STAT2. IFNGR1 constitutes the receptor ligand-binding alpha chain while the integral accessory factor IFNGR2 is required for signal transduction and may interact with GAF, JAK1, and/or JAK2. (NCI)NCI
DesignNote
  • Protein_Plays_Role_In_Biological_Process: Macrophage Activation
code
  • C37279
is someValuesFrom of
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