About: Interferon Alpha Receptor Complex     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Interferon Alpha Receptor Complex
rdfs:subClassOf
Semantic_Type
  • Receptor
Preferred_Name
  • Interferon Alpha Receptor Complex
UMLS_CUI
  • C0254653
Legacy_Concept_Name
  • Interferon_Alpha_Receptor_Complex
FULL_SYN
  • Interferon Alpha Receptor ComplexPTNCI
  • Interferon Beta ReceptorSYNCI
  • Interferon Alpha ReceptorSYNCI
  • Interferon-Alpha-Beta ReceptorSYNCI
DEFINITION
  • Human Interferon Alpha Receptor Complex (Type II Cytokine Family Receptor) is a ubiquitous type I membrane protein heteromeric receptor for type I IFNs, alpha and beta, composed of at least 2 chains, IFNAR1 (alpha chain) and IFNAR2 (beta chain). In mediating innate immune responses to viral infection and specific interferon inhibition of virus replication, binding of alpha and beta IFNs triggers tyrosine phosphorylation of JAKs, TYK2, STAT proteins, autophosphorylation, and tyrosine phosphorylation by TYK2. (NCI)NCI
code
  • C37274
sameAs
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